Production of the Alzheimer amyloid beta protein by normal proteolytic processing.

M, Shoji; TE, Golde; J, Ghiso; TT, Cheung; S, Estus; LM, Shaffer; XD, Cai; DM, McKay; R, Tintner; B, Frangione

doi:10.1126/science.1439760

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Production of the Alzheimer amyloid beta protein by normal proteolytic processing.

Shared by NobleBlocks on Oct 1, 1992 • 12:00 AM UTC

Authors:

Shoji M

Golde TE

Ghiso J

Abstract

The 4-kilodalton (39 to 43 amino acids) amyloid beta protein (beta AP), which is deposited as amyloid in the brains of patients with Alzheimer's diseases, is derived from a large protein, the amyloid beta protein precursor (beta APP). Human mononuclear leukemic (K562) cells expressing a beta AP-bear...

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