Nonsteroidal Antiinflammatory Drugs Inhibit the Proliferation of Colon Adenocarcinoma Cells: Effects on Cell Cycle and Apoptosis

J. Shiff, Steven; I. Koutsos, Markos; Qiao, Liang; Rigas, Basil

doi:10.1006/excr.1996.0023

Public

Nonsteroidal Antiinflammatory Drugs Inhibit the Proliferation of Colon Adenocarcinoma Cells: Effects on Cell Cycle and Apoptosis

Published in Experimental Cell Research • Jan 1, 1996

Authors:

Steven J. Shiff

Markos I. Koutsos

Liang Qiao

Abstract

Aspirin and other NSAIDs reduce the incidence of and mortality from colon cancer, but their mechanism of action remains unknown. We evaluated the effect of aspirin (ASA) and three other structurally unrelated NSAIDs (indomethacin, naproxen, and piroxicam) on cell proliferation, cell cycle phase dist...

Subject

Piroxicam

Cell cycle

Apoptosis

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