Mouse Embryonic Stem Cells, but Not Somatic Cells, Predominantly Use Homologous Recombination to Repair Double-Strand DNA Breaks

D. Tichy, Elisia; Pillai, Resmi; Deng, Li; Liang, Li; A. Tischfield, Jay; Schwemberger, Sandy; F. Babcock, George; J. Stambrook, Peter

doi:10.1089/scd.2010.0058

Public

Mouse Embryonic Stem Cells, but Not Somatic Cells, Predominantly Use Homologous Recombination to Repair Double-Strand DNA Breaks

Published in Stem Cells and Development • May 6, 2010

Authors:

Elisia D. Tichy

Resmi Pillai

Li Deng

Abstract

Embryonic stem (ES) cells give rise to all cell types of an organism. Since mutations at this embryonic stage would affect all cells and be detrimental to the overall health of an organism, robust mechanisms must exist to ensure that genomic integrity is maintained. To test this proposition, we comp...

Subject

Biology

Embryonic stem cell

DNA repair

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