Negative Correlation between Brain Glutathione Level and Negative Symptoms in Schizophrenia: A 3T 1H-MRS Study

Matsuzawa, Daisuke; Obata, Takayuki; Shirayama, Yukihiko; Nonaka, Hiroi; Kanazawa, Yôko; Yoshitome, Eiji; Takanashi, Jun‐ichi; Matsuda, Tsuyoshi; Shimizu, Eiji; Ikehira, Hiroo; Iyo, Masaomi; Hashimoto, Kenji

doi:10.1371/journal.pone.0001944

Public

Negative Correlation between Brain Glutathione Level and Negative Symptoms in Schizophrenia: A 3T 1H-MRS Study

Published in PLoS ONE • Apr 9, 2008

Authors:

Daisuke Matsuzawa

Takayuki Obata

Yukihiko Shirayama

Abstract

BACKGROUND: Glutathione (GSH), a major intracellular antioxidant, plays a role in NMDA receptor-mediated neurotransmission, which is involved in the pathophysiology of schizophrenia. In the present study, we aimed to investigate whether GSH levels are altered in the posterior medial frontal cortex o...

Subject

Stroop effect

Brief Psychiatric Rating Scale

Schizophrenia (object-oriented programming)

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