Targeted Administration into the Suprachoroidal Space Using a Microneedle for Drug Delivery to the Posterior Segment of the Eye

R. Patel, Samirkumar; E. Berezovsky, Damian; E. McCarey, Bernard; Zarnitsyn, Vladimir; F. Edelhauser, Henry; R. Prausnitz, Mark

doi:10.1167/iovs.12-9872

Public

Targeted Administration into the Suprachoroidal Space Using a Microneedle for Drug Delivery to the Posterior Segment of the Eye

Published in Investigative Ophthalmology & Visual Science • Jun 6, 2012

Authors:

Samirkumar R. Patel

Damian E. Berezovsky

Bernard E. McCarey

Abstract

PURPOSE: This study seeks to determine the intraocular pharmacokinetics of molecules and particles injected into the suprachoroidal space of the rabbit eye in vivo using a hollow microneedle. METHODS: Suprachoroidal injections of fluorescein and fluorescently tagged dextrans (40 and 250 kDa), bevaci...

Subject

Choroid

Posterior segment of eyeball

Fluorescein

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