High-performance liquid chromatography–tandem mass spectrometry in the identification and determination of phase I and phase II drug metabolites

Holčapek, Michal; Kolářová, Lenka; Nobilis, Milan

doi:10.1007/s00216-008-1962-7

Public

High-performance liquid chromatography–tandem mass spectrometry in the identification and determination of phase I and phase II drug metabolites

Published in Analytical and Bioanalytical Chemistry • Mar 14, 2008

Authors:

Michal Holčapek

Lenka Kolářová

Milan Nobilis

Abstract

Applications of tandem mass spectrometry (MS/MS) techniques coupled with high-performance liquid chromatography (HPLC) in the identification and determination of phase I and phase II drug metabolites are reviewed with an emphasis on recent papers published predominantly within the last 6 years (2002...

Subject

Chemistry

Chromatography

Mass spectrometry

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