Early Bactericidal Activity and Pharmacokinetics of the Diarylquinoline TMC207 in Treatment of Pulmonary Tuberculosis

Rustomjee, Roxana; H. Diacon, Andreas; Allen, Jenny; Venter, Amour; Reddy, Carl; F. Patientia, R.; Mthiyane, Thuli; De Marez, Tine; van Heeswijk, Rolf; Kerstens, René; Koul, A.; De Beule, K.; R. Donald, P.; F. McNeeley, D.

doi:10.1128/aac.01204-07

Public

Early Bactericidal Activity and Pharmacokinetics of the Diarylquinoline TMC207 in Treatment of Pulmonary Tuberculosis

Published in Antimicrobial Agents and Chemotherapy • May 28, 2008

Authors:

Roxana Rustomjee

Andreas H. Diacon

Jenny Allen

Abstract

Tibotec Medicinal Compound 207 (TMC207) is a novel diarylquinoline with a unique mode of action that targets mycobacterial ATP synthase. TMC207 exhibits high in vitro activity against mycobacterial strains either susceptible or resistant to all first-line and many second-line drugs, including fluoro...

Subject

Pharmacokinetics

Tuberculosis

Pulmonary tuberculosis

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