Activation of microglial N-methyl-D-aspartate receptors triggers inflammation and neuronal cell death in the developing and mature brain.

M Kaindl, Angela; Degos, Vincent; Peineau, Stéphane; Gouadon, Elodie; Chhor, Vibol; Loron, Gauthier; Le Charpentier, Tifenn; Josserand, Julien; Ali, Carine; Vivien, Denis; L Collingridge, Graham; Lombet, Alain; Issa, Lina; Rene, Frédérique; Loeffler, Jean-Philippe; Kavelaars, Annemieke; Verney, Catherine; Mantz, Jean; Gressens, Pierre

doi:10.1002/ana.23626

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Activation of microglial N-methyl-D-aspartate receptors triggers inflammation and neuronal cell death in the developing and mature brain.

Shared by NobleBlocks on Oct 1, 2012 • 12:00 AM UTC

Authors:

Angela M Kaindl

Vincent Degos

Stéphane Peineau

Abstract

OBJECTIVE: Activated microglia play a central role in the inflammatory and excitotoxic component of various acute and chronic neurological disorders. However, the mechanisms leading to their activation in the latter context are poorly understood, particularly the involvement of N-methyl-D-aspartate ...

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