Characterization of 5′AMP-activated protein kinase activity in the heart and its role in inhibiting acetyl-CoA carboxylase during reperfusion following ischemia

Kudo, Naomi; G. Gillespie, John; Kung, Lina; A. Witters, Lee; Schulz, Richard; S. Clanachan, Alexander; D. Lopaschuk, Gary

doi:10.1016/0005-2760(96)00013-6

Public

Characterization of 5′AMP-activated protein kinase activity in the heart and its role in inhibiting acetyl-CoA carboxylase during reperfusion following ischemia

Published in Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism • May 1, 1996

Authors:

Naomi Kudo

John G. Gillespie

Lina Kung

Abstract

Despite the high expression of 5'AMP activated protein kinase (AMPK) in heart, the activity and function of this enzyme in heart muscle has not been characterized. We demonstrate that rat hearts have a high AMPK activity, comparable to that found in liver, which could be stimulated up to 3-fold by 5...

Subject

AMPK

Protein kinase A

Acetyl-CoA carboxylase

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