Characterization of 5'AMP-activated protein kinase activity in the heart and its role in inhibiting acetyl-CoA carboxylase during reperfusion following ischemia.

N, Kudo; JG, Gillespie; L, Kung; LA, Witters; R, Schulz; AS, Clanachan; GD, Lopaschuk

doi:10.1016/0005-2760(96)00013-6

Public

Characterization of 5'AMP-activated protein kinase activity in the heart and its role in inhibiting acetyl-CoA carboxylase during reperfusion following ischemia.

Shared by NobleBlocks on May 1, 1996 • 12:00 AM UTC

Authors:

Kudo N

Gillespie JG

Kung L

Abstract

Despite the high expression of 5'AMP activated protein kinase (AMPK) in heart, the activity and function of this enzyme in heart muscle has not been characterized. We demonstrate that rat hearts have a high AMPK activity, comparable to that found in liver, which could be stimulated up to 3-fold by 5...

Research Assistant

AI chat, annotations, notes & similar papers

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!