Contribution of Intragenic DNA Methylation in Mouse Gametic DNA Methylomes to Establish Oocyte-Specific Heritable Marks

Kobayashi, Hisato; Sakurai, Takayuki; Imai, Misaki; Takahashi, Nozomi; Fukuda, Atsushi; Obata, Yayoi; Sato, Shun; Nakabayashi, Kazuhiko; Hata, Kenichiro; Sotomaru, Yusuke; Suzuki, Yutaka; Kono, Tomohiro

doi:10.1371/journal.pgen.1002440

Public

Contribution of Intragenic DNA Methylation in Mouse Gametic DNA Methylomes to Establish Oocyte-Specific Heritable Marks

Published in PLoS Genetics • Jan 5, 2012

Authors:

Hisato Kobayashi

Takayuki Sakurai

Misaki Imai

Abstract

Genome-wide dynamic changes in DNA methylation are indispensable for germline development and genomic imprinting in mammals. Here, we report single-base resolution DNA methylome and transcriptome maps of mouse germ cells, generated using whole-genome shotgun bisulfite sequencing and cDNA sequencing ...

Subject

Biology

DNA methylation

Genomic imprinting

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