L-type Ca2+ current downregulation in chronic human atrial fibrillation is associated with increased activity of protein phosphatases.

T, Christ; P, Boknik; S, Wöhrl; E, Wettwer; EM, Graf; RF, Bosch; M, Knaut; W, Schmitz; U, Ravens; D, Dobrev

doi:10.1161/01.cir.0000145659.80212.6a

Public

L-type Ca2+ current downregulation in chronic human atrial fibrillation is associated with increased activity of protein phosphatases.

Shared by NobleBlocks on Oct 18, 2004 • 12:00 AM UTC

Authors:

Christ T

Boknik P

Wöhrl S

Abstract

Background Although downregulation of L-type Ca2+ current (I(Ca,L)) in chronic atrial fibrillation (AF) is an important determinant of electrical remodeling, the molecular mechanisms are not fully understood. Here, we tested whether reduced I(Ca,L) in AF is associated with alterations in phosphoryla...

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