Induction of Apoptosis by ASK1, a Mammalian MAPKKK That Activates SAPK/JNK and p38 Signaling Pathways

Ichijo, Hidenori; Nishida, Eisuke; Irie, Kenji; ten Dijke, Peter; Saitoh, Masao; Moriguchi, Tetsuo; Takagi, Minoru; Matsumoto, Kunihiro; Miyazono, Kohei; Gotoh, Yukiko

doi:10.1126/science.275.5296.90

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Induction of Apoptosis by ASK1, a Mammalian MAPKKK That Activates SAPK/JNK and p38 Signaling Pathways

Published in Science • Jan 3, 1997

Authors:

Hidenori Ichijo

Eisuke Nishida

Kenji Irie

Abstract

Mitogen-activated protein (MAP) kinase cascades are activated in response to various extracellular stimuli, including growth factors and environmental stresses. A MAP kinase kinase kinase (MAPKKK), termed ASK1, was identified that activated two different subgroups of MAP kinase kinases (MAPKK), SEK1...

Subject

ASK1

MAP kinase kinase kinase

Mitogen-activated protein kinase kinase

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