Human Bone Marrow–Derived Mesenchymal Stem Cells Do Not Undergo Transformation after Long-term In vitro Culture and Do Not Exhibit Telomere Maintenance Mechanisms

Ester Bernardo, Maria; Zaffaroni, Nadia; Novara, Francesca; Cometa, Angela; Antonietta Avanzini, Maria; Moretta, Antonia; Montagna, Daniela; Maccario, Rita; Villa, Raffaella; Grazia Daidone, Maria; Zuffardi, Orsetta; Locatelli, Franco

doi:10.1158/0008-5472.can-06-4690

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Human Bone Marrow–Derived Mesenchymal Stem Cells Do Not Undergo Transformation after Long-term In vitro Culture and Do Not Exhibit Telomere Maintenance Mechanisms

Published in Cancer Research • Oct 1, 2007

Authors:

Maria Ester Bernardo

Nadia Zaffaroni

Francesca Novara

Abstract

Significant improvement in the understanding of mesenchymal stem cell (MSC) biology has opened the way to their clinical use. However, concerns regarding the possibility that MSCs undergo malignant transformation have been raised. We investigated the susceptibility to transformation of human bone ma...

Subject

Mesenchymal stem cell

Telomerase

Telomere

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