Identification of RNF213 as a Susceptibility Gene for Moyamoya Disease and Its Possible Role in Vascular Development

Liu, Wanyang; Morito, Daisuke; Takashima, Seiji; Mineharu, Yohei; Kobayashi, Hatasu; Hitomi, Toshiaki; Hashikata, Hirokuni; Matsuura, Norio; Yamazaki, Satoru; Toyoda, Atsushi; Kikuta, Ken‐ichiro; Takagi, Yasushi; H. Harada, Kouji; Fujiyama, Asao; Herzig, Roman; Krischek, Boris; Zou, Li‐Ping; Eun Kim, Jeong; Kitakaze, Masafumi; Miyamoto, Susumu; Nagata, Kazuhiro; Hashimoto, Nobuo; Koizumi, Akio

doi:10.1371/journal.pone.0022542

Public

Identification of RNF213 as a Susceptibility Gene for Moyamoya Disease and Its Possible Role in Vascular Development

Published in PLoS ONE • Jul 20, 2011

Authors:

Wanyang Liu

Daisuke Morito

Seiji Takashima

Abstract

BACKGROUND: Moyamoya disease is an idiopathic vascular disorder of intracranial arteries. Its susceptibility locus has been mapped to 17q25.3 in Japanese families, but the susceptibility gene is unknown. METHODOLOGY/PRINCIPAL FINDINGS: Genome-wide linkage analysis in eight three-generation families ...

Subject

Genetics

Haplotype

Moyamoya disease

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