Targeted disruption of the mouse <i>Stat3</i> gene leads to early embryonic lethality

Takeda, Kiyoshi; Noguchi, Koichi; Shi, Wei; Tanaka, Takashi; Matsumoto, Makoto; Yoshida, Nobuaki; Kishimoto, Tadamitsu; Akira, Shizuo

doi:10.1073/pnas.94.8.3801

Public

Targeted disruption of the mouse Stat3 gene leads to early embryonic lethality

Published in Proceedings of the National Academy of Sciences • Apr 15, 1997

Authors:

Kiyoshi Takeda

Koichi Noguchi

Wei Shi

Abstract

Signal transducer and activator of transcription (STAT) proteins have been shown to mediate biological actions in response to cytokines. Stat3, a member of the STAT family, is activated by a variety of cytokines, including the interleukin 6 family of cytokines, leptin, granulocyte colony-stimulating...

Subject

STAT3

STAT protein

Biology

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