The Eagle Effect Revisited: Efficacy of Clindamycin, Erythromycin, and Penicillin in the Treatment of Streptococcal Myositis

L. Stevens, Dennis; E. Gibbons, Anne; W Bergstrom, Richard; D. Winn, Virginia

doi:10.1093/infdis/158.1.23

Public

The Eagle Effect Revisited: Efficacy of Clindamycin, Erythromycin, and Penicillin in the Treatment of Streptococcal Myositis

Published in The Journal of Infectious Diseases • Jul 1, 1988

Authors:

Dennis L. Stevens

Anne E. Gibbons

Richard W Bergstrom

Abstract

We investigated the relative efficacies of penicillin, clindamycin, and erythromycin in a mouse model of myositis due to Streptococcus pyogenes. Penicillin was ineffective unless given at the time of bacterial injection, and treatment delays of 2 h reduced its efficacy such that survival was no bett...

Subject

Clindamycin

Penicillin

Erythromycin

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