Seven new loci associated with age-related macular degeneration

G. Fritsche, Lars; H. F. Weber, Bernhard; Chen, Wei; Sim, Xueling; R. Abecasis, Gonçalo; Schu, Matthew; Jun, Gyungah; A. Farrer, Lindsay; L. Yaspan, Brian; L. Haines, Jonathan; Yu, Yi; Chin, Kimberly; Reynolds, Robyn; M. Seddon, Johanna; Þorleifsson, Guðmar; Stefánsson, Hreinn; Stefánsson, Kāri; Þorsteinsdóttir, Unnur; J. Zack, Donald; Audo, Isabelle; Sahel, José‐Alain; Léveillard, Thierry; A. Campochiaro, Peter; Arakawa, Satoshi; Kubo, Michiaki; Cipriani, Valentina; C. Bird, Alan; T. Moore, Anthony; R. Webster, Andrew; R.W. Yates, John; Ripke, Stephan; J. Daly, Mark; P. Igo, Robert; Joseph, Peronne; Truitt, Barbara; K. Iyengar, Sudha; H.S. Buitendijk, Gabriëlle; G. Uitterlinden, André; M. van Duijn, Cornelia; R. Vingerling, Johannes; C. W. Klaver, Caroline; E. Weeks, Daniel; H. Guymer, Robyn; Cain, Melinda; J. Richardson, Andrea; Yin Wong, Tien; N. Baird, Paul; Jin Wang, Jie; E. Merriam, Joanna; R. Barile, Gaetano; Theodore Smith, R.; Allikmets, Rando; J. Francis, Peter; L. Klein, Michael; Hannum, Gregory; Agarwal, Anita; Maria Armbrecht, Ana; Dhillon, Baljean; Mohand‐Saïd, Saddek; Aung, Tin; Cheng, Ching‐Yu; K. Cornes, Belinda; N. Vithana, Eranga; Benchaboune, Mustapha; N. Bishop, Paul; Branham, Kari; R. Heckenlively, John; Othman, Mohammad; Swaroop, Anand; Brooks, Matthew; Cojocaru, Radu; S. Friedman, James; Gupta, Neel; Ratna Priya, Rinki; J. Brucker, Alexander; H. Cade, William; C. Naj, Adam; K. Scott, William; A. Pericak‐Vance, Margaret; P. N. Scholl, Hendrik; Chao Chan, Chi; Y. Chew, Emily; Chowers, Itay; Clayton, David; C. Khan, Jane; Shahid, Humma; P. Conley, Yvette; O. Edwards, Albert; Εvangelou, Εvangelos; Fagerness, Jesen; Ferreyra, Henry; Hughes, Guy; Kozak, Igor; J. Lee, Clara; Zhang, Ming; Zhao, Ling; Zhang, Kang; Geirsdóttir, Ásbjörg; Sigurðsson, Haraldur; George, Ronnie; Vijaya, Lingam; Gieger, Christian; M. Heid, Iris; A. Hagstrom, Stephanie; J. Pauer, Gayle; S. Peachey, Neal; Harding, Simon; Haritoglou, Christos; Rudolph, Guenther; G. Holz, Frank; P. A. Ioannidis, John; Ishibashi, Tatsuro; Kamatani, Yoichiro; Mark Lathrop, G; Katsanis, Nicholas; N. Keilhauer, Claudia; K. Kim, Ivana; A. Schaumberg, Debra; Sobrin, Lucia; Kiyohara, Yutaka; E.K. Klein, Barbara; Klein, Ronald; E. Lee, Kristine; E. Myers, Chelsea; L. Kovach, Jaclyn; G Schwartz, Stephen; Lichtner, Peter; Meitinger, Thomas; Lotery, Andrew; Mitchell, Paul; J. Morgan, Denise; A. Morrison, Margaux; M. DeAngelis, Margaret; Nakamura, Yusuke; Okada, Yukinori; Takahashi, Atsushi; Orlin, Anton; Carolina Ortube, Maria; B. Gorin, Michael; Pappas, Chris; S. Hageman, Gregory; Hyung Park, Kyu; M. Sturgill-Short, Gwen; Poch, Olivier; Ripp, Raymond; Ryu, Euijung; Tosakulwong, Nirubol; Silvestri, Giuliana; A. Sivakumaran, Theru; H. Souied, Eric; Stambolian, Dwight; E. Tsironi, Evangelia; Wichmann, H-Erich; W. Winkler, Thomas; F. Wright, Alan; Zélénika, Diana

doi:10.1038/ng.2578

Public

Seven new loci associated with age-related macular degeneration

Published in Nature Genetics • Mar 3, 2013

Authors:

Lars G. Fritsche

Bernhard H. F. Weber

Wei Chen

Abstract

Gonçalo Abecasis and colleagues report a large-scale meta-analysis of genome-wide association studies for age-related macular degeneration (AMD), including over 17,100 advanced cases and 60,000 controls. They identify seven loci newly associated with AMD and report pathway analysis that shows enrich...

Subject

Macular degeneration

Biology

Genetics

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