In adults with standard-risk acute lymphoblastic leukemia, the greatest benefit is achieved from a matched sibling allogeneic transplantation in first complete remission, and an autologous transplantation is less effective than conventional consolidation/maintenance chemotherapy in all patients: final results of the International ALL Trial (MRC UKALL XII/ECOG E2993)

H. Goldstone, Anthony; Richards, Susan; M. Lazarus, Hillard; S. Tallman, Martin; Buck, Georgina; K. Fielding, Adele; K. Burnett, Alan; Chopra, Raj; H. Wiernik, Peter; Foroni, Letizia; Paietta, Elisabeth; R. Litzow, Mark; I. Marks, David; Durrant, Jill; McMillan, Andrew; M. Franklin, Ian; M. Luger, Selina; Ciobanu, Niculae; M. Rowe, Jacob

doi:10.1182/blood-2007-10-116582

Public

In adults with standard-risk acute lymphoblastic leukemia, the greatest benefit is achieved from a matched sibling allogeneic transplantation in first complete remission, and an autologous transplantation is less effective than conventional consolidation/maintenance chemotherapy in all patients: final results of the International ALL Trial (MRC UKALL XII/ECOG E2993)

Published in Blood • Nov 29, 2007

Authors:

Anthony H. Goldstone

Susan Richards

Hillard M. Lazarus

Abstract

An international collaboration was set up to prospectively evaluate the role of allogeneic transplantation for adults with acute lymphoblastic leukemia (ALL) and compare autologous transplantation with standard chemotherapy. Patients received 2 phases of induction and, if in remission, were assigned...

Subject

Medicine

Transplantation

Randomized controlled trial

Research Assistant

AI chat, annotations, notes & similar papers

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!