The Orphan G Protein-coupled Receptors GPR41 and GPR43 Are Activated by Propionate and Other Short Chain Carboxylic Acids

J. Brown, Andrew; M. Goldsworthy, Susan; Barnes, Ashley; M. Eilert, Michelle; Tcheang, Lili; A. Daniels, Dion; I. Muir, Alison; Wigglesworth, Mark; J. Kinghorn, Ian; J. Fraser, Neil; B. Pike, Nicholas; C. Strum, Jay; Steplewski, Klaudia; R. Murdock, Paul; C. Holder, Julie; H. Marshall, Fiona; Szekeres, Philip; Wilson, Shelagh; M. Ignar, Diane; Foord, S.M.; Wise, Alan; J. Dowell, Simon

doi:10.1074/jbc.m211609200

Public

The Orphan G Protein-coupled Receptors GPR41 and GPR43 Are Activated by Propionate and Other Short Chain Carboxylic Acids

Published in Journal of Biological Chemistry • Mar 1, 2003

Authors:

Andrew J. Brown

Susan M. Goldsworthy

Ashley Barnes

Abstract

GPR41 and GPR43 are related members of a homologous family of orphan G protein-coupled receptors that are tandemly encoded at a single chromosomal locus in both humans and mice. We identified the acetate anion as an agonist of human GPR43 during routine ligand bank screening in yeast. This activity ...

Subject

Receptor

Biology

Biochemistry

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