Isoniazid Pharmacokinetics-Pharmacodynamics in an Aerosol Infection Model of Tuberculosis

Jayaram, Ramesh; Krishan Shandil, Radha; Gaonkar, Sheshagiri; Kaur, Parvinder; L. Suresh, B.; N. Mahesh, B.; Jayashree, R.; Nandi, Vrinda; Bharath, Sowmya; Kantharaj, E.; Balasubramanian, V.

doi:10.1128/aac.48.8.2951-2957.2004

Public

Isoniazid Pharmacokinetics-Pharmacodynamics in an Aerosol Infection Model of Tuberculosis

Published in Antimicrobial Agents and Chemotherapy • Jul 23, 2004

Authors:

Ramesh Jayaram

Radha Krishan Shandil

Sheshagiri Gaonkar

Abstract

Limited data exist on the pharmacokinetic-pharmacodynamic (PK-PD) parameters of the bactericidal activities of the available antimycobacterial drugs. We report on the PK-PD relationships for isoniazid. Isoniazid exhibited concentration (C)-dependent killing of Mycobacterium tuberculosis H37Rv in vit...

Subject

Isoniazid

Antimycobacterial

Pharmacodynamics

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