Role of<i>pfmdr1</i>Amplification and Expression in Induction of Resistance to Artemisinin Derivatives in<i>Plasmodium falciparum</i>

Chavchich, Marina; Gerena, Lucia; M. Peters, Jennifer; Chen, Nanhua; Cheng, Qin; E. Kyle, Dennis

doi:10.1128/aac.00947-09

Public

Role ofpfmdr1Amplification and Expression in Induction of Resistance to Artemisinin Derivatives inPlasmodium falciparum

Published in Antimicrobial Agents and Chemotherapy • Mar 30, 2010

Authors:

Marina Chavchich

Lucia Gerena

Jennifer M. Peters

Abstract

Artemisinin and its derivatives are the most rapidly acting and efficacious antimalarial drugs currently available. Although resistance to these drugs has not been documented, there is growing concern about the potential for resistance to develop. In this paper we report the selection of parasite re...

Subject

Mefloquine

Artemisinin

Plasmodium falciparum

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