Multiple homologues of LuxR and LuxI control expression of virulence determinants and secondary metabolites through quorum sensing in <i>Pseudomonas aeruginosa</i> PAO1

Latifi, Amel; K. Winson, Michael; Foglino, Maryline; W. Bycroft, Barrie; S. A. B. Stewart, Gordon; Lazdunski, Andrée; Williams, Paul

doi:10.1111/j.1365-2958.1995.mmi_17020333.x

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Multiple homologues of LuxR and LuxI control expression of virulence determinants and secondary metabolites through quorum sensing in Pseudomonas aeruginosa PAO1

Shared by NobleBlocks on Jul 1, 1995 • 12:00 AM UTC

Authors:

Amel Latifi

Michael K. Winson

Maryline Foglino

Abstract

In Pseudomonas aeruginosa PAO1, expression of elastase is dependent upon an interaction between the positive transcriptional activator LasR and the autoinducer molecule N (3‐oxododecanoyl)‐ l ‐homoserine lactone (OdDHL), the synthesis of which is directed by LasI. Previously we have shown that in PA...

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