Gonadal Determination and Adrenal Development Are Regulated by the Orphan Nuclear Receptor Steroidogenic Factor-1, in a Dose-Dependent Manner

C. Achermann, John; Özışık, Gökhan; Ito, Masafumi; Arman Örün, Utku; Harmancı, Koray; Gürakan, Berkan; Larry Jameson, J.

doi:10.1210/jcem.87.4.8376

Public

Gonadal Determination and Adrenal Development Are Regulated by the Orphan Nuclear Receptor Steroidogenic Factor-1, in a Dose-Dependent Manner

Published in The Journal of Clinical Endocrinology & Metabolism • Apr 1, 2002

Authors:

John C. Achermann

Gökhan Özışık

Masafumi Ito

Abstract

The orphan nuclear receptor steroidogenic factor-1 (SF-1, NR5A1) regulates the transcription of multiple genes involved in steroidogenesis, reproduction, and male sexual differentiation. A heterozygous loss-of-function SF-1 mutation (G35E) has been described in a patient with adrenal failure and com...

Subject

Steroidogenic factor 1

Nuclear receptor

Biology

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