Geneva Cocktail for Cytochrome P450 and P-Glycoprotein Activity Assessment Using Dried Blood Spots

Bosilkovska, Marija; Samer, Caroline; Déglon, Julien; Rebsamen, M.; Staub, C.; Dayer, Pierre; Walder, Bernhard; Desmeules, Jules; Daali, Youssef

doi:10.1038/clpt.2014.83

Public

Geneva Cocktail for Cytochrome P450 and P-Glycoprotein Activity Assessment Using Dried Blood Spots

Published in Clinical Pharmacology & Therapeutics • Apr 10, 2014

Authors:

Marija Bosilkovska

Caroline Samer

Julien Déglon

Abstract

The suitability of the capillary dried blood spot (DBS) sampling method was assessed for simultaneous phenotyping of cytochrome P450 (CYP) enzymes and P-glycoprotein (P-gp) using a cocktail approach. Ten volunteers received an oral cocktail capsule containing low doses of the probes bupropion (CYP2B...

Subject

CYP1A2

Pharmacology

Chemistry

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