Mesenchymal stem cells reciprocally regulate the M1/M2 balance in mouse bone marrow-derived macrophages

Cho, Dong-Im; Ra Kim, Mi; Yun Jeong, Hye; Chang Jeong, Hae; Ho Jeong, Myung; Ho Yoon, Sung; Sook Kim, Yong; Ahn, Youngkeun

doi:10.1038/emm.2013.135

Public

Mesenchymal stem cells reciprocally regulate the M1/M2 balance in mouse bone marrow-derived macrophages

Published in Experimental & Molecular Medicine • Jan 10, 2014

Authors:

Dong-Im Cho

Mi Ra Kim

Hye Yun Jeong

Abstract

Mesenchymal stem cells (MSCs) have been widely studied for their applications in stem cell-based regeneration. During myocardial infarction (MI), infiltrated macrophages have pivotal roles in inflammation, angiogenesis and cardiac remodeling. We hypothesized that MSCs may modulate the immunologic en...

Subject

Mesenchymal stem cell

Bone marrow

M2 Macrophage

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