Nuclear HBx binds the HBV minichromosome and modifies the epigenetic regulation of cccDNA function

Belloni, Laura; Pollicino, Teresa; De Nicola, Francesca; Guerrieri, Francesca; Raffa, G.; Fanciulli, Maurizio; Raimondo, Giovanni; Levrero, Massimo

doi:10.1073/pnas.0908365106

Public

Nuclear HBx binds the HBV minichromosome and modifies the epigenetic regulation of cccDNA function

Published in Proceedings of the National Academy of Sciences • Nov 11, 2009

Authors:

Laura Belloni

Teresa Pollicino

Francesca De Nicola

Abstract

HBV cccDNA, the template for transcription of all viral mRNAs, accumulates in the nucleus of infected cells as a stable episome organized into minichromosomes by histones and non-histone viral and cellular proteins. Using a cccDNA-specific chromatin immunoprecipitation (ChIP)-based quantitative assa...

Subject

cccDNA

HBx

Minichromosome

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