Mechanism of Autophagy to Apoptosis Switch Triggered in Prostate Cancer Cells by Antitumor Cytokine Melanoma Differentiation-Associated Gene 7/Interleukin-24

K. Bhutia, Sujit; Dash, Rupesh; K. Das, Swadesh; Azab, Belal; Su, Zhao-zhong; Lee, Seok‐Geun; Grant, Steven; Yacoub, Adly; Dent, Paul; T. Curiel, David; Sarkar, Devanand; B. Fisher, Paul

doi:10.1158/0008-5472.can-09-3647

Public

Mechanism of Autophagy to Apoptosis Switch Triggered in Prostate Cancer Cells by Antitumor Cytokine Melanoma Differentiation-Associated Gene 7/Interleukin-24

Published in Cancer Research • Apr 20, 2010

Authors:

Sujit K. Bhutia

Rupesh Dash

Swadesh K. Das

Abstract

Melanoma differentiation-associated gene 7 (mda-7)/interleukin-24 (IL-24) is a unique member of the IL-10 gene family, which displays a broad range of antitumor properties, including induction of cancer-specific apoptosis. Adenoviral-mediated delivery by Ad.mda-7 invokes an endoplasmic reticulum (ER...

Subject

Autophagy

ATG5

Prostate cancer

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