Combination Therapy with Epidermal Growth Factor and Gastrin Induces Neogenesis of Human Islet β-Cells from Pancreatic Duct Cells and an Increase in Functional β-Cell Mass

L. Suarez‐Pinzon, Wilma; R.T. Lakey, Jonathan; J. Brand, Stephen; Rabinovitch, Alex

doi:10.1210/jc.2004-0761

Public

Combination Therapy with Epidermal Growth Factor and Gastrin Induces Neogenesis of Human Islet β-Cells from Pancreatic Duct Cells and an Increase in Functional β-Cell Mass

Published in The Journal of Clinical Endocrinology & Metabolism • May 25, 2005

Authors:

Wilma L. Suarez‐Pinzon

Jonathan R.T. Lakey

Stephen J. Brand

Abstract

Pancreatic islet transplantation is a viable treatment for type 1 diabetes, but is limited by human donor tissue availability. The combination of epidermal growth factor (EGF) and gastrin induces islet beta-cell neogenesis from pancreatic exocrine duct cells in rodents. In this study we investigated...

Subject

Internal medicine

Endocrinology

Gastrin

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