Genome plasticity of BCG and impact on vaccine efficacy

Brosch, Roland; V. Gordon, Stephen; Garnier, Thierry; Eiglmeier, Karin; Frigui, Wafa; Valenti, Philippe; Dos Santos, Sandrine; Duthoy, Stéphanie; Lacroix, Céline; García-Pelayo, Carmen; Inwald, Jacqueline; Golby, Paul; Nuñez Garcia, Javier; Glyn Hewinson, R.; A. Behr, Marcel; A. Quail, Michael; Churcher, Carol; Barrell, Bart; Parkhill, Julian; T. Cole, Stewart

doi:10.1073/pnas.0700869104

Public

Genome plasticity of BCG and impact on vaccine efficacy

Published in Proceedings of the National Academy of Sciences • Mar 19, 2007

Authors:

Roland Brosch

Stephen V. Gordon

Thierry Garnier

Abstract

To understand the evolution, attenuation, and variable protective efficacy of bacillus Calmette-Guérin (BCG) vaccines, Mycobacterium bovis BCG Pasteur 1173P2 has been subjected to comparative genome and transcriptome analysis. The 4,374,522-bp genome contains 3,954 protein-coding genes, 58 of which ...

Subject

Biology

Gene

Immunogenicity

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