Antibody landscapes after influenza virus infection or vaccination

M. Fonville, J.; H. Wilks, S.; L. James, S.; Fox, A.; Ventresca, M.; Aban, M.; Xue, L.; C. Jones, T.; N. M. H., Le; Q. T., Pham; N. D., Tran; Wong, Y.; Mosterin, A.; C. Katzelnick, L.; Labonte, D.; T. T., Le; van der Net, G.; Skepner, E.; A. Russell, C.; D. Kaplan, T.; F. Rimmelzwaan, G.; Masurel, N.; C. de Jong, J.; Palache, A.; E. P. Beyer, W.; Q. M., Le; T. H., Nguyen; F. L. Wertheim, H.; C. Hurt, A.; D. M. E. Osterhaus, A.; G. Barr, I.; A. M. Fouchier, R.; W. Horby, P.; J. Smith, D.

doi:10.1126/science.1256427

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Antibody landscapes after influenza virus infection or vaccination

Shared by NobleBlocks on Nov 21, 2014 • 12:00 AM UTC

Authors:

J. M. Fonville

S. H. Wilks

S. L. James

Abstract

We introduce the antibody landscape, a method for the quantitative analysis of antibody-mediated immunity to antigenically variable pathogens, achieved by accounting for antigenic variation among pathogen strains. We generated antibody landscapes to study immune profiles covering 43 years of influen...

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