Antibody landscapes after influenza virus infection or vaccination

M. Fonville, Judith; Wilks, Samuel; L. James, Sarah; Fox, Annette; Ventresca, Mariangela; Aban, Malet; Xue, Lumin; C. Jones, Terry; N. M. H., Le; Quang Thái, Phạm; Tran, Nam; Wong, Y.; Mosterín, Ana; C. Katzelnick, Leah; Labonte, David; Tao, Le; van der Net, Guido; Skepner, Eugene; A. Russell, Colin; Kaplan, Tommy; F. Rimmelzwaan, Guus; Masurel, N.; de Jong, J.C.; Palache, A.M.; Beyer, W.E.P.; Quellec-Nathan M, Le; Thanh Hải, Nguyễn; Wertheim, Heiman; C. Hurt, Aeron; D. M. E. Osterhaus, Albert; Barr, Ian; A. M. Fouchier, Ron; Horby, Peter; J. Smith, Derek

doi:10.1126/science.1256427

Public

Antibody landscapes after influenza virus infection or vaccination

Published in Science • Nov 20, 2014

Authors:

Judith M. Fonville

Samuel Wilks

Sarah L. James

Abstract

We introduce the antibody landscape, a method for the quantitative analysis of antibody-mediated immunity to antigenically variable pathogens, achieved by accounting for antigenic variation among pathogen strains. We generated antibody landscapes to study immune profiles covering 43 years of influen...

Subject

Vaccination

Virology

Original antigenic sin

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