Gene Dose of Apolipoprotein E Type 4 Allele and the Risk of Alzheimer's Disease in Late Onset Families

H. Corder, E.; M. Saunders, A.; J. Strittmatter, W.; E. Schmechel, D.; C. Gaskell, P.; W. Small, G.; D. Roses, A.; L. Haines, J.; A. Pericak-Vance, M.

doi:10.1126/science.8346443

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Gene Dose of Apolipoprotein E Type 4 Allele and the Risk of Alzheimer's Disease in Late Onset Families

Shared by NobleBlocks on Aug 13, 1993 • 12:00 AM UTC

Authors:

E. H. Corder

A. M. Saunders

W. J. Strittmatter

Abstract

The apolipoprotein E type 4 allele ( APOE -ε4) is genetically associated with the common late onset familial and sporadic forms of Alzheimer's disease (AD). Risk for AD increased from 20% to 90% and mean age at onset decreased from 84 to 68 years with increasing number of APOE -ε4 alleles in 42 fami...

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