Regulation of Matrix Metalloproteinases (MMP-2, -3, -9, and -13) by Interleukin-1 and Interleukin-6 in Mouse Calvaria: Association of MMP Induction with Bone Resorption*

Kusano, Kenichiro; Miyaura, Chisato; Inada, Masaki; Tamura, Tatsuya; Itô, Akira; Nagase, Hideaki; Kamoi, Kyuichi; Suda, Tatsuo

doi:10.1210/endo.139.3.5818

Public

Regulation of Matrix Metalloproteinases (MMP-2, -3, -9, and -13) by Interleukin-1 and Interleukin-6 in Mouse Calvaria: Association of MMP Induction with Bone Resorption*

Published in Endocrinology • Mar 1, 1998

Authors:

Kenichiro Kusano

Chisato Miyaura

Masaki Inada

Abstract

Interleukin-1 (IL-1) greatly induces osteoclast formation and stimulates bone resorption of mouse calvaria in culture. In the presence of soluble IL-6 receptor (sIL-6R), IL-6 similarly induces osteoclast formation, but the potency of IL-6 in inducing bone resorption in organ culture is weaker than t...

Subject

Calvaria

Matrix metalloproteinase

Bone resorption

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