DNA oxidation matters: The HPLC–electrochemical detection assay of 8-oxo-deoxyguanosine and 8-oxo-guanine

J. Helbock, Harold; B. Beckman, Kenneth; K. Shigenaga, Mark; B. Walter, Patrick; Woodall, Alan; Yeo, Helen; N. Ames, Bruce

doi:10.1073/pnas.95.1.288

Public

DNA oxidation matters: The HPLC–electrochemical detection assay of 8-oxo-deoxyguanosine and 8-oxo-guanine

Published in Proceedings of the National Academy of Sciences • Jan 6, 1998

Authors:

Harold J. Helbock

Kenneth B. Beckman

Mark K. Shigenaga

Abstract

Oxidative DNA damage is important in aging and the degenerative diseases of aging such as cancer. Estimates commonly rely on measurements of 8-oxo-2'-deoxyguanosine (oxo8dG), an adduct that occurs in DNA and is also excreted in urine after DNA repair. Here we examine difficulties inherent in the ana...

Subject

Guanine

Deoxyguanosine

Chemistry

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