Role of Brain Insulin Receptor in Control of Body Weight and Reproduction

C. Brüning, Jens; Gautam, Dinesh; J. Burks, Deborah; A. Gillette, Jennifer; Schubert, Markus; C. Orban, Paul; Klein, Rüdiger; Krone, Wilhelm; Müller‐Wieland, Dirk; Ronald Kahn, C.

doi:10.1126/science.289.5487.2122

Public

Role of Brain Insulin Receptor in Control of Body Weight and Reproduction

Published in Science • Sep 22, 2000

Authors:

Jens C. Brüning

Dinesh Gautam

Deborah J. Burks

Abstract

Insulin receptors (IRs) and insulin signaling proteins are widely distributed throughout the central nervous system (CNS). To study the physiological role of insulin signaling in the brain, we created mice with a neuron-specific disruption of the IR gene (NIRKO mice). Inactivation of the IR had no i...

Subject

Endocrinology

Internal medicine

Leptin

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