Reciprocal T
                    <sub>H</sub>
                    17 and Regulatory T Cell Differentiation Mediated by Retinoic Acid

Mucida, Daniel; Park, Yunji; Kim, Gisen; Turovskaya, Olga; Scott, Iain; Kronenberg, Mitchell; Cheroutre, Hilde

doi:10.1126/science.1145697

Public

Reciprocal T H 17 and Regulatory T Cell Differentiation Mediated by Retinoic Acid

Published in Science • Jul 13, 2007

NobleIDark:/48914/w1/20260526/8BD343CDRecord on NobleID

Authors:

Daniel Mucida

,

Yunji Park

,

Gisen Kim

Abstract

The cytokine transforming growth factor–β (TGF-β) converts naïve T cells into regulatory T (Treg) cells that prevent autoimmunity. However, in the presence of interleukin-6 (IL-6), TGF-β has also been found to promote the differentiation of naïve T lymphocytes into proinflammatory IL-17 cytokine-p...

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