Irinotecan Fluorouracil Plus Leucovorin Is Not Superior to Fluorouracil Plus Leucovorin Alone As Adjuvant Treatment for Stage III Colon Cancer: Results of CALGB 89803

B. Saltz, Leonard; Niedzwiecki, Donna; Hollis, Donna; M. Goldberg, Richard; Hantel, Alexander; P. Thomas, James; Fields, Anthony; J. Mayer, Robert

doi:10.1200/jco.2007.11.2144

Public

Irinotecan Fluorouracil Plus Leucovorin Is Not Superior to Fluorouracil Plus Leucovorin Alone As Adjuvant Treatment for Stage III Colon Cancer: Results of CALGB 89803

Published in Journal of Clinical Oncology • Aug 8, 2007

Authors:

Leonard B. Saltz

Donna Niedzwiecki

Donna Hollis

Abstract

PURPOSE: Randomized studies have shown that irinotecan (CPT-11) extends survival in metastatic colorectal cancer patients when administered in second-line and when added to fluorouracil (FU) plus leucovorin (LV) in first-line therapy of metastatic colorectal cancer. When this study was initiated, FU...

Subject

Medicine

Irinotecan

Fluorouracil

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