Rapid Pneumococcal Evolution in Response to Clinical Interventions

J. Croucher, Nicholas; R. Harris, Simon; Fraser, Christophe; A. Quail, Michael; H. Burton, John; van der Linden, Mark; McGee, Lesley; von Gottberg, Anne; Hoon Song, Jae; Soo Ko, Kwan; Pichon, Bruno; Baker, Stephen; M. Parry, Christopher; Lambertsen, Lotte; Shahinas, Dea; R. Pillai, Dylan; J. Mitchell, Timothy; Dougan, Gordon; Tomasz, Alexander; P. Klugman, Keith; Parkhill, Julian; P. Hanage, William; D. Bentley, Stephen

doi:10.1126/science.1198545

Public

Rapid Pneumococcal Evolution in Response to Clinical Interventions

Published in Science • Jan 27, 2011

Authors:

Nicholas J. Croucher

Simon R. Harris

Christophe Fraser

Abstract

Epidemiological studies of the naturally transformable bacterial pathogen Streptococcus pneumoniae have previously been confounded by high rates of recombination. Sequencing 240 isolates of the PMEN1 (Spain(23F)-1) multidrug-resistant lineage enabled base substitutions to be distinguished from polym...

Subject

Biology

Lineage (genetic)

Streptococcus pneumoniae

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!