Coordinated Control of Endothelial Nitric-oxide Synthase Phosphorylation by Protein Kinase C and the cAMP-dependent Protein Kinase

J. Michell, Belinda; Chen, Zhiping; Tiganis, Tony; Stapleton, David; Katsis, Frosa; A. Power, David; T.R. Sim, Alistair; E. Kemp, Bruce

doi:10.1074/jbc.c100122200

Public

Coordinated Control of Endothelial Nitric-oxide Synthase Phosphorylation by Protein Kinase C and the cAMP-dependent Protein Kinase

Published in Journal of Biological Chemistry • May 1, 2001

Authors:

Belinda J. Michell

Zhiping Chen

Tony Tiganis

Abstract

Endothelial nitric-oxide synthase (eNOS) is an important regulatory enzyme in the cardiovascular system catalyzing the production of NO from arginine. Multiple protein kinases including Akt/PKB, cAMP-dependent protein kinase (PKA), and the AMP-activated protein kinase (AMPK) activate eNOS by phospho...

Subject

Dephosphorylation

Phosphorylation

Enos

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