Transforming Growth Factor-β Function Blocking Prevents Myocardial Fibrosis and Diastolic Dysfunction in Pressure-Overloaded Rats

Kuwahara, Fumitaka; Kai, Hisashi; Tokuda, Keisuke; Kai, Mamiko; Takeshita, Akira; Egashira, Kensuke; Imaizumi, Tsutomu

doi:10.1161/01.cir.0000020689.12472.e0

Public

Transforming Growth Factor-β Function Blocking Prevents Myocardial Fibrosis and Diastolic Dysfunction in Pressure-Overloaded Rats

Published in Circulation • Jul 2, 2002

Authors:

Fumitaka Kuwahara

Hisashi Kai

Keisuke Tokuda

Abstract

BACKGROUND: Excessive myocardial fibrosis impairs cardiac function in hypertensive hearts. Roles of transforming growth factor (TGF)-beta in myocardial remodeling and cardiac dysfunction were examined in pressure-overloaded rats. METHODS AND RESULTS: Pressure overload was induced by a suprarenal aor...

Subject

Medicine

Pressure overload

Myocardial fibrosis

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