Bloom’s Syndrome and PICH Helicases Cooperate with Topoisomerase IIα in Centromere Disjunction before Anaphase

Rouzeau, Sébastien; P. Cordelières, Fabrice; Buhagiar‐Labarchède, Géraldine; Hurbain, Ilse; Onclercq-Delic, Rosine; Gemble, Simon; Magnaghi-Jaulin, Laura; Jaulin, Christian; Amor-Guéret, Mounira

doi:10.1371/journal.pone.0033905

Public

Bloom’s Syndrome and PICH Helicases Cooperate with Topoisomerase IIα in Centromere Disjunction before Anaphase

Published in PLoS ONE • Apr 26, 2012

Authors:

Sébastien Rouzeau

Fabrice P. Cordelières

Géraldine Buhagiar‐Labarchède

Abstract

Centromeres are specialized chromosome domains that control chromosome segregation during mitosis, but little is known about the mechanisms underlying the maintenance of their integrity. Centromeric ultrafine anaphase bridges are physiological DNA structures thought to contain unresolved DNA catenat...

Subject

Anaphase

Centromere

Prometaphase

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