Single phosphorylation sites in Acc1 and Acc2 regulate lipid homeostasis and the insulin-sensitizing effects of metformin

D. Fullerton, Morgan; Galić, Sandra; Marcinko, Katarina; R. Sikkema, Sarah; Pulinilkunnil, Thomas; Chen, Zhiping; M. O’Neill, Hayley; J. Ford, Rebecca; Palanivel, Rengasamy; T. O’Brien, Matthew; Grahame Hardie, D.; Lance Macaulay, S.; D. Schertzer, Jonathan; R.B. Dyck, Jason; J. van Denderen, Bryce; E. Kemp, Bruce; R. Steinberg, Gregory

doi:10.1038/nm.3372

Public

Single phosphorylation sites in Acc1 and Acc2 regulate lipid homeostasis and the insulin-sensitizing effects of metformin

Published in Nature Medicine • Nov 3, 2013

Authors:

Morgan D. Fullerton

Sandra Galić

Katarina Marcinko

Abstract

Metformin is one of the most widely prescribed therapeutics for type 2 diabetes. But exactly how it works is still unclear. Gregory Steinberg and colleagues now show that it does so by activation of the enzyme AMP-activated protein kinase (Ampk) and Ampk's obligate targeting of two key enzymes invol...

Subject

AMPK

Metformin

Lipogenesis

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