The Crystal Structure of the Globular Head of Complement Protein C1q Provides a Basis for Its Versatile Recognition Properties

Gaboriaud, Christine; Juanhuix, Judith; Gruez, Arnaud; Lacroix, Monique; Darnault, Claudine; Pignol, David; Verger, Denis; C. Fontecilla‐Camps, Juan; J. Arlaud, Gérard

doi:10.1074/jbc.m307764200

Public

The Crystal Structure of the Globular Head of Complement Protein C1q Provides a Basis for Its Versatile Recognition Properties

Published in Journal of Biological Chemistry • Nov 1, 2003

Authors:

Christine Gaboriaud

Judith Juanhuix

Arnaud Gruez

Abstract

C1q is a versatile recognition protein that binds to an amazing variety of immune and non-immune ligands and triggers activation of the classical pathway of complement. The crystal structure of the C1q globular domain responsible for its recognition properties has now been solved and refined to 1.9 ...

Subject

Heterotrimeric G protein

Complement system

Classical complement pathway

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