Natively Inhibited
                    <i>Trypanosoma brucei</i>
                    Cathepsin B Structure Determined by Using an X-ray Laser

Redecke, Lars; Nass, Karol; P. DePonte, Daniel; A. White, Thomas; Rehders, Dirk; Barty, Anton; Stellato, Francesco; Liang, Mengning; R.M. Barends, Thomas; Boutet, Sébastien; J. Williams, Garth; Messerschmidt, Marc; Marvin Seibert, M.; Aquila, Andrew; Arnlund, David; Bajt, Sasa; Barth, Torsten; J. Bogan, Michael; Caleman, Carl; Chao, Tzu-Chiao; Bruce Doak, R.; Fleckenstein, Holger; Frank, Matthias; Fromme, Raimund; Galli, Lorenzo; Grotjohann, Ingo; S. Hunter, Mark; C. Johansson, Linda; Kassemeyer, Stephan; Katona, Gergely; A. Kirian, Richard; Koopmann, Rudolf; Kupitz, Chris; Lomb, Lukas; V. Martin, Andrew; Mogk, Stefan; Neutze, Richard; L. Shoeman, Robert; Steinbrener, Jan; Timneanu, Nicusor; Wang, Dingjie; Weierstall, Uwe; A. Zatsepin, Nadia; C. H. Spence, John; Fromme, Petra; Schlichting, Ilme; Duszenko, Michael; Betzel, Christian; N. Chapman, Henry

doi:10.1126/science.1229663

Public

Natively Inhibited Trypanosoma brucei Cathepsin B Structure Determined by Using an X-ray Laser

Shared by NobleBlocks on Jan 11, 2013 • 12:00 AM UTC

Authors:

Lars Redecke

Karol Nass

Daniel P. DePonte

Abstract

Diffraction Before Destruction A bottleneck in x-ray crystallography is the growth of well-ordered crystals large enough to obtain high-resolution diffraction data within an exposure that limits radiation damage. Serial femtosecond crystallography promises to overcome these constraints by using shor...

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