Natively Inhibited <i>Trypanosoma brucei</i> Cathepsin B Structure Determined by Using an X-ray Laser

Redecke, Lars; Nass, Karol; P. DePonte, Daniel; A. White, Thomas; Rehders, D.; Barty, Anton; Stellato, Francesco; Liang, Mengning; Barends, T.R.M.; Boutet, Sébastien; J. Williams, Garth; Messerschmidt, M.; Seibert, M.; Aquila, Andrew; Arnlund, David; Bajt, S.; Barth, Torsten; J. Bogan, Michael; Caleman, Carl; Chao, Tzu‐Chiao; Bruce Doak, R.; Fleckenstein, Holger; Frank, Matthias; Fromme, Raimund; Galli, Lorenzo; Grotjohann, Ingo; S. Hunter, Mark; C. Johansson, Linda; Kassemeyer, Stephan; Katona, Gergely; A. Kirian, Richard; Koopmann, Rudolf; Kupitz, Chris; Lomb, Lukas; V. Martin, Andrew; Mogk, Stefan; Neutze, Richard; L. Shoeman, Robert; Steinbrener, Jan; Tı̂mneanu, Nicuşor; Wang, Dingjie; Weierstall, Uwe; A. Zatsepin, Nadia; C. H. Spence, John; Fromme, Petra; Schlichting, Ilme; Duszenko, Michael; Betzel, Christian; N. Chapman, Henry

doi:10.1126/science.1229663

Public

Natively Inhibited Trypanosoma brucei Cathepsin B Structure Determined by Using an X-ray Laser

Published in Science • Nov 30, 2012

Authors:

Lars Redecke

Karol Nass

Daniel P. DePonte

Abstract

The Trypanosoma brucei cysteine protease cathepsin B (TbCatB), which is involved in host protein degradation, is a promising target to develop new treatments against sleeping sickness, a fatal disease caused by this protozoan parasite. The structure of the mature, active form of TbCatB has so far no...

Subject

Trypanosoma brucei

Cathepsin B

Cysteine protease

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