Differential Pathogenesis of Lung Adenocarcinoma Subtypes Involving Sequence Mutations, Copy Number, Chromosomal Instability, and Methylation

D. Wilkerson, Matthew; Yin, Xiaoying; Walter, Vonn; Zhao, Ni; R. Cabanski, Christopher; C. Hayward, Michele; Ryan Miller, C.; A. Socinski, Mark; M. Parsons, Alden; B. Thorne, Leigh; E. Haithcock, Benjamin; K. Veeramachaneni, Nirmal; K. Funkhouser, William; H. Randell, Scott; S. Bernard, Philip; M. Perou, Charles; Neil Hayes, D.

doi:10.1371/journal.pone.0036530

Public

Differential Pathogenesis of Lung Adenocarcinoma Subtypes Involving Sequence Mutations, Copy Number, Chromosomal Instability, and Methylation

Published in PLoS ONE • May 10, 2012

Authors:

Matthew D. Wilkerson

Xiaoying Yin

Vonn Walter

Abstract

BACKGROUND: Lung adenocarcinoma (LAD) has extreme genetic variation among patients, which is currently not well understood, limiting progress in therapy development and research. LAD intrinsic molecular subtypes are a validated stratification of naturally-occurring gene expression patterns and encom...

Subject

KRAS

Biology

Adenocarcinoma

Research Assistant

AI chat, annotations, notes & similar papers

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!