Mechanistic Aspects and Novel Biomarkers of Responder and Non-Responder Phenotypes in Galactosamine-Induced Hepatitis

Coen, Muireann; J. Want, Elizabeth; Andrew Clayton, T.; M. Rhode, Cynthia; Shick Hong, Young; C. Keun, Hector; H. Cantor, Glenn; Metz, Alan; G. Robertson, Donald; D. Reily, Michael; Holmes, Elaine; C. Lindon, John; K. Nicholson, Jeremy

doi:10.1021/pr9005266

Public

Mechanistic Aspects and Novel Biomarkers of Responder and Non-Responder Phenotypes in Galactosamine-Induced Hepatitis

Published in Journal of Proteome Research • Oct 12, 2009

Authors:

Muireann Coen

Elizabeth J. Want

T. Andrew Clayton

Abstract

The amino sugar galactosamine (galN) induces alterations in the hepatic uridine nucleotide pool and has been widely used as a model of human viral hepatitis. Histopathological and clinical chemistry analyses of a cohort of rats following administration of galN revealed extreme interindividual variab...

Subject

Galactosamine

Feces

Urine

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