Nonsteroid drug selectivities for cyclo-oxygenase-1 rather than cyclo-oxygenase-2 are associated with human gastrointestinal toxicity: A full <i>in vitro</i> analysis

D. Warner, Timothy; Giuliano, Francesco; Vojnovic, Ivana; Bukasa, Antoaneta; A. Mitchell, Jane; R. Vane, John

doi:10.1073/pnas.96.13.7563

Public

Nonsteroid drug selectivities for cyclo-oxygenase-1 rather than cyclo-oxygenase-2 are associated with human gastrointestinal toxicity: A full in vitro analysis

Published in Proceedings of the National Academy of Sciences • Jun 22, 1999

Authors:

Timothy D. Warner

Francesco Giuliano

Ivana Vojnovic

Abstract

The beneficial actions of nonsteroid anti-inflammatory drugs (NSAID) can be associated with inhibition of cyclo-oxygenase (COX)-2 whereas their harmful side effects are associated with inhibition of COX-1. Here we report data from two related assay systems, the human whole blood assay and a modified...

Subject

Rofecoxib

Celecoxib

Pharmacology

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