Global analysis of gene expression in pulmonary fibrosis reveals distinct programs regulating lung inflammation and fibrosis

Kaminski, Naftali; Allard, John; Pittet, Jean‐François; Zuo, Fengrong; Griffiths, Mark; G. Morris, David; Huang, Xiaozhu; Sheppard, Dean; A. Heller, Renu

doi:10.1073/pnas.97.4.1778

Public

Global analysis of gene expression in pulmonary fibrosis reveals distinct programs regulating lung inflammation and fibrosis

Published in Proceedings of the National Academy of Sciences • Feb 15, 2000

Authors:

Naftali Kaminski

John Allard

Jean‐François Pittet

Abstract

The molecular mechanisms of pulmonary fibrosis are poorly understood. We have used oligonucleotide arrays to analyze the gene expression programs that underlie pulmonary fibrosis in response to bleomycin, a drug that causes lung inflammation and fibrosis, in two strains of susceptible mice (129 and ...

Subject

Bleomycin

Fibrosis

Pulmonary fibrosis

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