Tuberculosis Associated with Infliximab, a Tumor Necrosis Factor α–Neutralizing Agent

Keane, Joseph; K. Gershon, Sharon; P. Wise, Robert; Mirabile‐Levens, Elizabeth; Kasznica, John; D. Schwieterman, William; Siegel, Jeffrey; Miles Braun, M.

doi:10.1056/nejmoa011110

Public

Tuberculosis Associated with Infliximab, a Tumor Necrosis Factor α–Neutralizing Agent

Published in New England Journal of Medicine • Oct 11, 2001

Authors:

Joseph Keane

Sharon K. Gershon

Robert P. Wise

Abstract

BACKGROUND: Infliximab is a humanized antibody against tumor necrosis factor alpha (TNF-alpha) that is used in the treatment of Crohn's disease and rheumatoid arthritis. Approximately 147,000 patients throughout the world have received infliximab. Excess TNF-alpha in association with tuberculosis ma...

Subject

Medicine

Infliximab

Tuberculosis

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