Induction of thymidine phosphorylase expression and enhancement of efficacy of capecitabine or 5?-deoxy-5-fluorouridine by cyclophosphamide in mammary tumor models

Endo, Mika; Shinbori, Noriko; Fukase, Yu; Sawada, Noriaki; Ishikawa, Tohru; Ishitsuka, Hideo; Tanaka, Yutaka

doi:10.1002/(sici)1097-0215(19990924)83:1<127::aid-ijc22>3.0.co;2-6

Public

Induction of thymidine phosphorylase expression and enhancement of efficacy of capecitabine or 5?-deoxy-5-fluorouridine by cyclophosphamide in mammary tumor models

Published in International Journal of Cancer • Sep 24, 1999

Authors:

Mika Endo

Noriko Shinbori

Yu Fukase

Abstract

Thymidine phosphorylase (dThdPase) is an essential enzyme for the activation of the oral cytostatic drugs capecitabine (N(4)-pentyloxycarbonyl-5'-deoxy-5-fluorocytidine, Xeloda(trade mark)) and its intermediate metabolite doxifluridine [5'-deoxy-5-fluorouridine (5'-dFUrd, Furtulon((R)))] to 5-fluoro...

Subject

Capecitabine

Thymidine phosphorylase

Tegafur

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