Age‐related decrease in stimulated glutamate release and vesicular glutamate transporters in APP/PS1 transgenic and wild‐type mice

Minkeviciene, Rimante; Ihalainen, Jouni; Malm, Tarja; Matilainen, Olli; Keksa-Goldsteine, Velta; Goldsteins, Gundars; Iivonen, H.; Leguit, N.; Glennon, Jeffrey; Koıstınaho, Jari; Banerjee, Pradeep; Tanila, Heikki

doi:10.1111/j.1471-4159.2007.05147.x

Public

Age‐related decrease in stimulated glutamate release and vesicular glutamate transporters in APP/PS1 transgenic and wild‐type mice

Published in Journal of Neurochemistry • Nov 27, 2007

Authors:

Rimante Minkeviciene

Jouni Ihalainen

Tarja Malm

Abstract

We assessed baseline and KCl-stimulated glutamate release by using microdialysis in freely moving young adult (7 months) and middle-aged (17 months) transgenic mice carrying mutated human amyloid precursor protein and presenilin genes (APdE9 mice) and their wild-type littermates. In addition, we ass...

Subject

Glutamate receptor

Synaptophysin

Microdialysis

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